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Cell-specific activation of gemcitabine by endogenous H2S stimulation and tracking through simultaneous fluorescence
Mrinmoy Maiti1, Shin A Yoon2, Yujin Cha2
1Department of Science, School of Engineering, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India.
Abstract:
The endogenous H2S-driven theranostic H2S-Gem has been invented. The theranostic prodrug H2S-Gem is selectively activated in cancer cells, releasing active gemcitabine with a simultaneous fluorescence turn-on. H2S-Gem selectively inhibited cancer cell growth compared to the mother chemotherapeutic gemcitabine. Overall, it is a unique protocol for tracking and transporting chemotherapeutic agents to tumor areas without the guidance of tumor-directive ligands.
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