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Updated: Oct 21, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Physiological assessment after percutaneous coronary intervention: the hard truth
Giuseppe Zimbardo1, Pio Cialdella1, Federico DI Giusto2
1Ospedale Policlinico Casilino, Rome, Italy.
Physiological assessment using fractional flow reserve (FFR) or instantaneous wave free ratio (iFR) improves outcomes after percutaneous coronary intervention (PCI). Optimizing PCI based on these measures, even after visually successful procedures, is crucial for better patient results.
Area of Science:
- Cardiology
- Interventional Cardiology
- Physiological Assessment
Background:
- Physiologically guided revascularization (FFR/iFR) improves long-term outcomes compared to angiography alone.
- The role of post-percutaneous coronary intervention (PCI) physiological assessment is less established.
- Many patients with angiographically successful PCI have suboptimal functional results, impacting prognosis.
Purpose of the Study:
- To review the paradigm shift in invasive physiological assessment for PCI.
- To define the transition from pre-PCI guidance to post-PCI optimization.
- To propose a practical flowchart for physiologically optimizing PCI.
Main Methods:
- Review of existing evidence on physiological assessment in PCI.
- Analysis of the impact of functional results post-PCI.
- Development of a strategic approach for physiological optimization.
Main Results:
- Physiological assessment post-PCI can identify suboptimal results despite angiographic success.
- Accepting and addressing suboptimal physiological findings can lead to improved outcomes.
- A shift towards a comprehensive physiological approach to PCI is supported by evidence.
Conclusions:
- Invasive physiological assessment is evolving beyond pre-PCI decision-making.
- Post-PCI physiological optimization is essential for maximizing treatment benefits.
- A structured, physiological approach to PCI is recommended for improved patient care.
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