Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Harnessing Supramolecular J-Aggregates in Deep Eutectic Solvents for Tunable NIR Photothermal and Photodynamic Therapy.

Nano letters·2026

Same author

Nanomotor-Assisted Intravesical Chemotherapy for Bladder Tumor Reduction and Suppression of Early Tumor Regrowth.

Nano letters·2026

Same author

Eutectozymes as Soft Hybrid Materials for Advanced Biocatalysis.

Advanced materials (Deerfield Beach, Fla.)·2025

Same author

Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications.

Advanced materials (Deerfield Beach, Fla.)·2025

Same author

Terpene-Based Eutectic Solvent Microdroplets: A Strategy to Combat Antibiotic-Resistant <i>Helicobacter pylori</i>.

Langmuir : the ACS journal of surfaces and colloids·2025

Same author

Bioengineering fascicle-like skeletal muscle bioactuators via pluronic-assisted co-axial 3D bioprinting (PACA-3D).

Biofabrication·2025

Search research articles

Related Experiment Video

Updated: Oct 21, 2025

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

Nanocarriers for Skin Applications: Where Do We Stand?

Neha Tiwari¹, Ernesto Rafael Osorio-Blanco¹, Ana Sonzogni²

¹POLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country, UPV/EHU, Paseo Manuel de Lardizabal 3, 20018, Donostia-San Sebastián, Spain.

Angewandte Chemie (International Ed. in English)

|September 6, 2021

Summary

Nanoparticles offer a promising solution for enhanced skin drug delivery, overcoming low permeability and minimizing damage to the skin barrier. This review explores nanoparticle applications, safety, and clinical progress for effective dermal treatments.

Keywords:

drug delivery gene expression nanoparticles skin penetration transdermal vaccination

More Related Videos

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

Related Experiment Videos

Last Updated: Oct 21, 2025

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

Area of Science:

* Pharmaceutical Sciences
* Biomedical Engineering
* Nanotechnology

Background:

* Dermal drug delivery offers advantages like easy accessibility and reduced systemic side effects.
* Low skin permeability and aggressive penetration methods pose significant challenges.
* Nanocarrier systems present a minimally invasive alternative for enhanced skin penetration.

Purpose of the Study:

* To review the application of nanoparticles for delivering drugs, genetic material, and vaccines into the skin.
* To highlight nanotoxicology studies and clinical advancements of nanoparticles for dermal delivery.
* To assess the market translation potential of nanoparticle-based skin delivery systems.

Main Methods:

* Comprehensive literature review on nanoparticle-based dermal delivery systems.
* Analysis of existing nanotoxicology data for skin applications.
* Examination of recent clinical trials and regulatory developments for nanoparticles.

Main Results:

* Nanoparticles effectively enhance skin penetration of various therapeutic agents.
* Nanocarrier systems demonstrate minimal damage to the skin's natural barrier function.
* Emerging nanotoxicology data and clinical studies support the safety and efficacy of nanoparticles.

Conclusions:

* Nanoparticles represent a viable and minimally invasive strategy for advanced dermal drug delivery.
* Further research in nanotoxicology and clinical development is crucial for market translation.
* Nanotechnology holds significant potential to revolutionize the treatment of skin-related and systemic diseases via dermal routes.