The Efficacy Of Azithromycin Plus Levamisole Vs Azithromycin Alone In The Treatment Of Moderate To Severe Acne

Area of Science:

• Dermatology
• Pharmacology
• Clinical Trials

Background:

• Acne vulgaris (AV) affects over 85% of teenagers, with 30% requiring medical treatment.
• The pilosebaceous unit is affected by this common inflammatory disorder.
• Incidence rates of AV are similar between genders.

Purpose of the Study:

• To compare the efficacy of azithromycin plus levamisole versus azithromycin alone in treating moderate to severe acne.
• To evaluate treatment outcomes based on the Acne Global Severity Score.

Main Methods:

• A single-center randomized controlled trial involving 118 acne patients.
• Patients received either azithromycin plus levamisole or azithromycin alone for 8 weeks.
• Severity was assessed using the Acne Global Severity Score before and after treatment.

Main Results:

• The combination therapy group (azithromycin plus levamisole) demonstrated higher efficacy.
• The study included 118 patients, with a mean age of 20.10 years.
• The majority of patients had severe acne (52.5%).

Conclusions:

• Azithromycin plus levamisole is a more effective treatment for acne compared to azithromycin monotherapy.
• Combination therapy is supported for achieving better therapeutic results in acne patients.