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Correlation between Topographic Progression of Geographic Atrophy and Visual Acuity Changes
Jong In You1, Do Gyun Kim2, Seung-Young Yu1
1Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea.
Korean Journal of Ophthalmology : KJO
|September 6, 2021
Summary
Geographic atrophy progression in the parafoveal area, not the total area, significantly impacts visual acuity decline in patients. This finding highlights the importance of monitoring specific zones for predicting vision loss.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Medical Imaging
Background:
- Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD).
- GA leads to progressive and irreversible vision loss.
- Understanding the topographic progression of GA is crucial for predicting visual acuity outcomes.
Purpose of the Study:
- To analyze the topographic progression of geographic atrophy (GA) in concentric zones around the fovea.
- To correlate GA progression in different zones with the decrease in visual acuity.
- To identify specific areas of GA progression that most significantly impact vision.
Main Methods:
- Retrospective analysis of 36 eyes from 26 patients with diagnosed GA.
- Defined concentric zones: 1mm foveal center (zone 1), and 1-2mm to 5-6mm (zones 2-6).
- Measured GA area changes using semi-automatic software and performed correlation/regression analyses.
Main Results:
- Mean follow-up was 3.38 years; mean GA area increased from 8.09 to 16.34 mm2.
- Visual acuity decreased significantly (0.39 to 0.69 logMAR).
- GA progression in zones 1, 2, and 3 (parafoveal areas) showed a significant correlation with visual acuity decrease (p < 0.05).
Conclusions:
- Total geographic atrophy area progression did not significantly correlate with visual acuity decrease.
- Progression of geographic atrophy in the parafoveal area is significantly associated with reduced visual acuity.
- Monitoring GA progression in specific parafoveal zones is critical for predicting vision loss in AMD patients.
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