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Related Experiment Video

Updated: Oct 21, 2025

Characterizing Extracellular Vesicles from Biological Fluids

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

Intraocular Exosomes in Eye Diseases.

Hui Zhang¹, Xiaomin Zhang¹, Xiaorong Li¹

¹Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.

Current Molecular Medicine

|September 7, 2021

Summary

Intraocular exosomes, tiny vesicles in eye fluids, are key to intercellular communication and disease. This review explores their role in eye conditions like glaucoma and AMD.

Keywords:

Exosomes age-related macular degeneration aqueous humor extracellular vesicles glaucoma vitreous humor

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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

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Published on: February 6, 2021

Area of Science:

Ophthalmology
Cell Biology
Extracellular Vesicles Research

Background:

Exosomes are nanosized extracellular vesicles (30-150nm) found in all biological fluids, mediating intercellular communication.
They carry diverse biomaterials including mRNA, miRNA, and proteins.
While exosome roles in cancer are well-studied, their significance in ocular tissues is an emerging area.

Purpose of the Study:

To review recent advances in understanding intraocular exosomes.
To explore the contribution of intraocular exosomes to the pathogenesis and progression of major eye diseases.
To highlight the role of exosomes in ocular pathologies such as ECM remodeling, inflammation, and barrier dysfunction.

Main Methods:

Literature review of recent studies on intraocular exosomes and eye diseases.
Analysis of exosome involvement in pathological processes within the eye.
Synthesis of current knowledge on exosome function in glaucoma, AMD, myopia, and ocular tumors.

Main Results:

Intraocular exosomes are implicated in the pathogenesis of various eye diseases.
These vesicles contribute to ECM remodeling, retinal inflammation, and blood-retinal barrier dysfunction.
Specific roles in glaucoma, age-related macular degeneration, myopia, and ocular tumors are discussed.

Conclusions:

Intraocular exosomes are critical mediators in the development and progression of multiple ocular diseases.
Further research into intraocular exosomes offers potential for novel diagnostic and therapeutic strategies in ophthalmology.
Understanding exosome function in the eye is crucial for advancing treatments for blinding conditions.