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Prognosis for sarcoidosis in a defined geographical area
1Department of Medicine, University Central Hospital, Oulu, Finland.
British Journal of Diseases of the Chest
|October 1, 1987
Summary
Sarcoidosis patients in northern Finland showed a favorable prognosis, with most achieving normal chest X-rays and improved lung function over time. Few experienced significant fibrosis or required disability pensions.
Area of Science:
- Pulmonary Medicine
- Immunology
Background:
- Sarcoidosis is an inflammatory disease of unknown cause.
- Long-term outcomes and prognosis of sarcoidosis require further investigation.
Purpose of the Study:
- To evaluate the long-term prognosis of sarcoidosis.
- To assess radiological and functional outcomes in patients diagnosed with sarcoidosis.
Main Methods:
- A cohort of 199 sarcoidosis patients diagnosed between 1970-1976 in northern Finland was followed for 5-12 years.
- Chest X-rays and lung function tests (FEV1, FVC, DCO) were performed at follow-up.
Main Results:
- 83% of stage I and 58% of stage II sarcoidosis patients had normal chest X-rays at follow-up.
- Lung function (FEV1, FVC) generally improved, though DCO showed more abnormalities.
- Only 2 patients received disability pensions; 6 died from non-sarcoidosis causes.
Conclusions:
- Sarcoidosis generally has a favorable long-term prognosis with potential for radiological and functional recovery.
- Development of fibrosis is associated with poorer functional outcomes.