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Updated: Oct 21, 2025
Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
Published on: May 21, 2013
Integration of heterologous bone matrix associated with polymethylmethacrylate in induced tibial bone defects. An
Silvio Henrique De Freitas1, Alois Foltran Müller2, Thaís Ribeiro Fadel3
1MSc, PhD, Associate Professor. Veterinary Medicine Department (ZMV) - Faculty of Animal Sciences and Food Engineering (FZEA) - Universidade de São Paulo (USP) - Pirassununga (SP), Brazil.
Purpose:
To analyze and compare the reactions at the interface between the composite, composed of fragmented heterologous mineralized bone matrix (MOMHF) and polymethylmethacrylate (PMMA), and the rabbit's tibias, through macroscopic evaluation and scanning electron microscopy (SEM) in different periods.
Methods:
In this study, 12 New Zealand adult rabbits were used (E1: n = 3, E2: n = 3, E3: n = 3 and E4: n = 3). They had the right tibial defects filled with composite and were evaluated immediately after surgery and at 30, 60, 90, and 120 days.
Results:
The composites were incorporated and integrated into the recipient beds in 100% of the cases, defined by the MOMHF osseointegration and the PMMA fibrointegration, with no sign of infection, migration, or rejection.
Conclusions:
The behavior of the composites in the recipient beds demonstrates that these biomaterials have the potential to be used in bone defect repairs, offering, thus, better quality of life to the orthopedic patient.
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