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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Updated: Oct 21, 2025

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
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Extending human healthspan and longevity: a symposium report.

Loren M DeVito1, Nir Barzilai2, Ana Maria Cuervo2

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|September 9, 2021
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The geroscience hypothesis suggests aging is malleable, not inevitable. Targeting aging mechanisms may prevent age-related diseases and extend healthspan, with clinical trials underway.

Keywords:
biological aginggerosciencehallmarks of aginghealthspanlongevity

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Area of Science:

  • Gerontology
  • Biomedical Research
  • Aging Mechanisms

Background:

  • Historically, aging and age-related diseases were considered irreversible.
  • The geroscience hypothesis challenges this view, proposing aging is a targetable process.

Purpose of the Study:

  • To explore the geroscience hypothesis and its implications for healthspan.
  • To review advancements in targeting biological aging pathways.
  • To discuss challenges and progress in clinical translation of geroscience therapies.

Main Methods:

  • Review of current geroscience literature and research.
  • Analysis of advancements in understanding aging mechanisms.
  • Examination of novel and repurposed therapies targeting aging.

Main Results:

  • Significant progress has been made in understanding aging mechanisms.
  • Novel and repurposed therapies targeting aging pathways have been identified.
  • Early-stage clinical trials are evaluating the feasibility of geroscience interventions.

Conclusions:

  • Geroscience offers a paradigm shift, viewing aging as a malleable process.
  • Targeting hallmarks of aging holds promise for preventing multiple age-related diseases.
  • Clinical development faces hurdles, but ongoing trials aim to establish a regulatory pathway for future therapies.