Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 21, 2025

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

9.5K

Extrusion-based 3D (Bio)Printed Tissue Engineering Scaffolds: Process-Structure-Quality Relationships.

Samuel Gerdes1, Srikanthan Ramesh2, Azadeh Mostafavi1

  • 1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0526, United States.

ACS Biomaterials Science & Engineering
|September 9, 2021
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination.

Nature communications·2026
Same author

Self-sustaining media-reconstituted GelMA bioink supports printable hematopoietic cultures.

Biomaterials science·2026
Same author

3D Printed In Vitro Engineered Living Material Models for Antimicrobial Development.

ACS applied bio materials·2026
Same author

Effect of Hydrodynamic Shear Stress on Algal Cell Fate in 3D Extrusion Bioprinting.

Advanced engineering materials·2025
Same author

Correction to "Mechanical and Biochemical Stimulation of 3D Multilayered Scaffolds for Tendon Tissue Engineering".

ACS biomaterials science & engineering·2025
Same author

Correction to "<i>In Situ</i> Printing of Adhesive Hydrogel Scaffolds for the Treatment of Skeletal Muscle Injuries".

ACS applied bio materials·2025
This summary is machine-generated.

Biological additive manufacturing (Bio-AM) creates tissue scaffolds but can introduce defects affecting mechanical properties and cell response. This review details extrusion-based Bio-AM, defect causes, detection, and future research directions.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Additive Manufacturing

Background:

  • Biological additive manufacturing (Bio-AM) offers precise fabrication of biomimetic scaffolds for tissue engineering.
  • However, Bio-AM processes are prone to defects that compromise scaffold integrity and biological performance.

Purpose of the Study:

  • To review extrusion-based Bio-AM processes for scaffold fabrication.
  • To identify factors contributing to scaffold defects and their impact on mechanical properties and cellular responses.
  • To discuss defect detection methods and future research directions.

Main Methods:

  • Review of extrusion-based Bio-AM techniques.
  • Analysis of architectural and mechanotransduction parameters influencing cell-scaffold interactions.
Keywords:
3D printingBio-AMdefectsmaterial rheologyscaffoldstissue engineering

More Related Videos

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
07:05

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

10.2K
Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.3K

Related Experiment Videos

Last Updated: Oct 21, 2025

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

9.5K
Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer
07:05

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

10.2K
Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.3K
  • Examination of defect formation mechanisms and detection tools.

    • Main Results:

    • Bio-AM defects stem from material issues, processing parameters, environmental factors, and design flaws.
    • These defects significantly alter scaffold mechanical properties and lead to unpredictable cellular behavior.
    • Various tools exist for detecting defects in fabricated scaffolds.

    Conclusions:

    • Addressing defects in Bio-AM is crucial for reliable tissue engineering scaffold development.
    • Further research is needed to overcome current limitations and advance Bio-AM technologies.
    • Optimizing Bio-AM processes will enhance scaffold performance and predictability.