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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Related Experiment Video

Updated: Oct 21, 2025

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
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Regenerative Liver Surgery - ALPPS and Associated Techniques.

Florin Botea, Alexandru Barcu, Cosmin Verdea

    Chirurgia (Bucharest, Romania : 1990)
    |September 9, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Regenerative liver surgery enhances tumor resectability by stimulating liver regrowth. Associated Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) is a key technique, expanding treatment options for complex liver tumors.

    Keywords:
    ALPPScholangiocarcinomacolorectallivermetastaseshepatocellularcarcinomaregenerativeliversurgery

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    Area of Science:

    • Hepatobiliary surgery
    • Surgical oncology
    • Regenerative medicine

    Background:

    • Hepatectomy is the sole curative option for liver tumors but is limited by tumor location and extent.
    • Complex cases with multiple, bilobar, or hilum-adjacent lesions pose significant surgical challenges.
    • Regenerative liver surgery aims to increase tumor resectability by promoting future liver remnant (FLR) growth.

    Purpose of the Study:

    • To review current regenerative liver surgery techniques.
    • To focus on Associated Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS).
    • To discuss ALPPS mechanisms, indications, outcomes, and future directions.

    Main Methods:

    • Review of existing literature on regenerative liver surgery techniques.
    • Detailed examination of the ALPPS procedure, including its variants.
    • Analysis of liver regeneration mechanisms stimulated by these techniques.

    Main Results:

    • Regenerative techniques, particularly ALPPS, significantly enhance the resectability of challenging liver tumors.
    • ALPPS involves portal vein ligation and parenchymal transection to induce FLR hypertrophy.
    • Various ALPPS modifications exist, all targeting improved resectability.

    Conclusions:

    • Regenerative liver surgery, especially ALPPS, offers advanced strategies for managing complex hepatic tumors.
    • Understanding ALPPS mechanisms is crucial for optimizing patient selection and outcomes.
    • Further research and technical refinements are expected to expand the application of these techniques.