Related Experiment Video
Updated: Oct 21, 2025
07:26
Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis
Published on: April 1, 2022
2.1K
FGF8-mediated signaling regulates tooth developmental pace during odontogenesis
Chensheng Lin1, Ningsheng Ruan1, Linjun Li1
1Fujian Key Laboratory of Developmental and Neural Biology and Southern Center for Biomedical Research, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian 350117, China.
Journal of Genetics and Genomics = Yi Chuan Xue Bao
|September 9, 2021
Summary
Dental mesenchyme controls tooth development speed. Fibroblast Growth Factor 8 (FGF8) signaling in this tissue promotes cell growth and slows tooth development pace in mammals.
Area of Science:
- Developmental Biology
- Genetics
- Cell Biology
Background:
- Human and mouse teeth offer a conserved model for studying organ growth regulation.
- Significant variations in developmental tempo exist between species.
Purpose of the Study:
- To investigate the regulatory mechanisms controlling organ growth tempo.
- To identify key signaling pathways and tissue interactions in dental development.
Main Methods:
- Utilized heterogenous recombination between human and mouse dental tissues.
- Analyzed the role of Fibroblast Growth Factor 8 (FGF8) signaling in dental mesenchyme.
Main Results:
- Demonstrated that dental mesenchyme dictates tooth developmental tempo.
- Showed that FGF8 signaling activation in mouse dental mesenchyme enhances cell proliferation and inhibits apoptosis.
- Observed FGF8 signaling impelling the G1- to S-phase transition in the tooth germ cell cycle, slowing developmental pace.
Conclusions:
- Extrinsic signals significantly influence tooth developmental tempo.
- Dental mesenchymal FGF8 is a pivotal factor controlling mammalian odontogenesis pace non-cell-autonomously.
Related Concept Videos
01:16TGF - β Signaling Pathway
8.0K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
8.0K
02:33Hedgehog Signaling Pathway
7.8K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.8K
03:14Notch Signaling Pathway
4.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.6K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.2K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
01:22Diversity in Cell Signaling Responses
7.0K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
7.0K
01:29Bone Formation by Intramembranous Ossification
8.6K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
8.6K