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Silver Nanoparticle-Coated Polyhydroxyalkanoate Based Electrospun Fibers for Wound Dressing Applications
Ozlem Ipek Kalaoglu-Altan1,2, Havva Baskan1,2, Timo Meireman1
1Department of Materials, Textiles and Chemical Engineering, Ghent University, 9000 Ghent, Belgium.
Materials (Basel, Switzerland)
|September 10, 2021
Summary
This study developed advanced wound dressings using bio-based nanofibers. These silver-nanoparticle-infused materials promote skin regeneration and exhibit antimicrobial properties, offering promising solutions for advanced wound care.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Wound dressings are crucial for skin regeneration, requiring bioresorption and biocompatibility.
- Polyhydroxyalkanoates (PHAs) are bio-based polymers known for biocompatibility and skin regenerative potential.
Purpose of the Study:
- To advance wound dressing technology using nanofabrication and natural antimicrobial materials.
- To create novel PHA-based nanofibers for enhanced wound healing applications.
Main Methods:
- Electrospinning a blend of poly(3-hydroxybutyrate) (P(3HB)) and poly(3-hydroxyoctanoate-co-3-hydroxy decanoate) (P(3HO-co-3HD)) into nanofibers.
- Modifying the P(3HB))/P(3HO-co-3HD) nanofibers with silver nanoparticles (AgNPs) using a dip-coating technique.
Main Results:
- The resulting silver-containing nanofiber meshes demonstrated good cytocompatibility in vitro.
- These materials exhibited immunomodulatory properties and stimulated human beta defensin 2 and cytokeratin expression in keratinocytes (HaCaT cells).
Conclusions:
- The developed silver-nanoparticle-modified PHA nanofibers show significant potential as advanced wound dressing materials.
- These materials offer a promising combination of biocompatibility, regenerative properties, and antimicrobial activity for improved wound healing.
