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Correlation between Cerebrospinal Fluid IL-12 Levels and Severity of Encephalopathy in Children

Hisashi Kawashima1, Shinichiro Morichi1, Gaku Yamanaka1

  • 1Department of Pediatrics and Adolescent Medicine, Tokyo Medical University, Tokyo 160-0023, Japan.

Journal of Clinical Medicine
|September 10, 2021
PubMed

Insights

Interleukin-12 (IL-12) is elevated in the cerebrospinal fluid of children with encephalopathy, correlating with clinical symptoms. This finding clarifies the role of IL-12 in pediatric neurological complications.

Area of Science:

  • Neuroscience
  • Immunology
  • Pediatrics

Background:

  • Cytokine roles in cerebrospinal fluid (CSF) in acute encephalopathy are poorly understood.
  • Infection-associated neurological complications in children require further investigation into underlying mechanisms.

Purpose of the Study:

  • To investigate the profiles of 26 cytokines in the CSF of children with infection-associated neurological complications.
  • To determine the specific role and correlation of Interleukin-12 (IL-12) in pediatric encephalopathy.

Main Methods:

  • Analysis of 26 cytokine profiles in the CSF of 17 pediatric patients.
  • Quantitative measurement of IL-12 (p70) levels and comparison between patient groups.
  • Correlation analysis between IL-12 levels and other cytokines (PDGF-bb, IL-RA, IFN-γ, VEGF).

Main Results:

  • Elevated IL-12 (p70) levels were observed in most pediatric patients with encephalopathy.
  • IL-12 levels in CSF showed strong correlations with PDGF-bb, IL-RA, and VEGF.
  • Weak correlation was found between IL-12 and IFN-γ levels.

Conclusions:

  • IL-12 is significantly increased in the CSF of children with encephalopathy.
  • IL-12 levels are associated with other key cytokines and may influence clinical symptoms in pediatric encephalopathy.
  • Further research into IL-12's impact on neurological complications is warranted.

Keywords:
IL-12 p70IL-7NOxVEGFinfluenza

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