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The Relationship between Serum Uric Acid and Ejection Fraction of the Left Ventricle

Ivan Vlad-Sabin1, Buzas Roxana1, Cuțina Morgovan Adina-Flavia1

  • 1Advanced Research Center for Cardiovascular Pathology and Haemostaseology, Department of Internal Medicine I-Medical Semiology I, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Journal of Clinical Medicine
|September 10, 2021
PubMed

Insights

Higher serum uric acid levels are linked to a lower ejection fraction in heart failure patients. This finding suggests a potential role for uric acid in cardiovascular disease progression, even in asymptomatic cases.

Area of Science:

  • Cardiology
  • Metabolic Disorders

Background:

  • Serum uric acid, a byproduct of protein metabolism, is a debated risk factor in cardiovascular disease.
  • The precise role of serum uric acid in the development of cardiac pathologies is under investigation.

Purpose of the Study:

  • To investigate the direct relationship between serum uric acid levels and left ventricular ejection fraction.
  • To determine if serum uric acid is independently associated with reduced ejection fraction in heart failure.

Main Methods:

  • Retrospective analysis of 303 heart failure patients.
  • Classification according to European Society of Cardiology (ESC) guidelines.
  • Characterization of serum uric acid levels and ejection fraction, alongside other parameters.

Main Results:

  • A statistically significant direct relationship was found between serum uric acid and ejection fraction (p=0.03).
  • Patients with elevated serum uric acid levels demonstrated an increased risk of lower ejection fraction.
  • This association persisted even in asymptomatic individuals.

Conclusions:

  • Serum uric acid is significantly associated with left ventricular ejection fraction in heart failure.
  • Elevated uric acid may serve as a biomarker for impaired cardiac function.
  • Further research is warranted to explore the clinical implications of this association.

Keywords:
ejection fractionheart failurehyperuricemiaserum uric acid

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