Related Experiment Video

Updated: Aug 5, 2026

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction
03:42

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Published on: March 29, 2024

Hyperuricemia Reflects Cardiometabolic Burden Rather than Left Ventricular Systolic Dysfunction Across Heart Failure

Raluca Ibănescu1,2,3,4, Sebastian Ciurescu4, Roxana Buzaș1,2,3

  • 1Advanced Cardiology and Haemostaseology Research Center, "Victor Babeș" University of Medicine and Pharmacy, No. 2 Eftimie Murgu Square, 300041 Timișoara, Romania.

Journal of Clinical Medicine
|July 28, 2026
PubMed

Insights

Serum uric acid does not independently predict reduced ejection fraction in acute heart failure (AHF). Elevated uric acid levels reflect metabolic distress and congestion, not direct heart dysfunction.

Area of Science:

  • Cardiology
  • Biochemistry
  • Internal Medicine

Background:

  • Acute heart failure (AHF) is a major cause of illness worldwide, requiring effective biomarkers for risk assessment.
  • Hyperuricemia is common in heart failure patients; it may indicate cardiometabolic distress rather than cause heart dysfunction.

Purpose of the Study:

  • To investigate if serum uric acid independently predicts left ventricular ejection fraction (LVEF) in patients with AHF.
  • To assess the diagnostic utility of uric acid in differentiating heart failure phenotypes.

Main Methods:

  • Retrospective analysis of 306 AHF patients from a tertiary hospital.
  • Statistical analysis included correlation, t-tests, and multivariable linear/logistic regression.
  • Adjusted for comorbidities and diuretic use when analyzing LVEF predictors.

Main Results:

  • Hyperuricemia was observed in 64.6% of the study cohort.
  • Serum uric acid did not significantly predict LVEF variance (p=0.356).
  • Uric acid showed no diagnostic utility in classifying heart failure phenotypes (OR=0.995, p=0.973).

Conclusions:

  • Serum uric acid is not an independent predictor of reduced LVEF in AHF.
  • Elevated uric acid likely reflects systemic metabolic issues and diuretic effects, not direct cardiac pathology.

Keywords:
acute heart failureleft ventricular ejection fractionserum uric acid

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