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Injectable Thixotropic β-Cyclodextrin-Functionalized Hydrogels Based on Guanosine Quartet Assembly.

Monica-Cornelia Sardaru1, Irina Rosca1, Simona Morariu2

  • 1Centre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley 41 A, Iasi 700487, Romania.

International Journal of Molecular Sciences
|September 10, 2021
PubMed
Summary

Researchers developed new β-cyclodextrin-functionalized hydrogels using guanosine quartet assembly. These self-healing, antimicrobial hydrogels show tunable properties, making them promising for biomedical applications.

Keywords:
antimicrobial activityguanosine quartetinjectable hydrogelsupramolecular hydrogelβ–cyclodextrin

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Area of Science:

  • Materials Science
  • Supramolecular Chemistry
  • Biomedical Engineering

Background:

  • Hydrogels are versatile materials with applications in drug delivery and tissue engineering.
  • Supramolecular assembly offers a route to create functional hydrogels with tunable properties.
  • β-cyclodextrin and guanosine are known for their molecular recognition and self-assembly capabilities.

Purpose of the Study:

  • To develop a facile method for preparing β-cyclodextrin-functionalized hydrogels.
  • To investigate the effect of component ratios on hydrogel structure and properties.
  • To explore the potential of these hydrogels in biomedical and pharmaceutical applications.

Main Methods:

  • Hydrogels were synthesized by linking β-cyclodextrin and guanosine using a benzene-1,4-diboronic acid linker.
  • Potassium ions were used as reticulation agents to form guanosine quartets.
  • Characterization involved circular dichroism, electron microscopy (SEM, AFM), X-ray diffraction, and rheological measurements.

Main Results:

  • Seven transparent, self-sustained hydrogels were successfully prepared.
  • Varying the β-cyclodextrin to guanosine ratio influenced hydrogel structuration and mechanical properties.
  • Rheological studies confirmed self-healing and thixotropic behavior.
  • Antimicrobial activity against *S. aureus* was observed, dependent on the component ratio.

Conclusions:

  • The study presents a facile method for creating tunable β-cyclodextrin-functionalized hydrogels via guanosine quartet assembly.
  • These hydrogels exhibit promising self-healing, thixotropic, and selective antimicrobial properties.
  • The tunable nature and functional cavities make them suitable for drug delivery and biomedical applications.