Naringin and Naringenin Functionalized Silver Nanoparticles: Synthesis, Characterization and Biological Evaluation

Area of Science:

• Nanotechnology
• Green Chemistry
• Materials Science

Background:

• Flavonoids are explored for green synthesis of metallic nanoparticles.
• Research on pure naringin (NG) and naringenin (NGN) for silver nanoparticle (AgNP) synthesis is limited.

Purpose of the Study:

• To synthesize and characterize silver nanoparticles (AgNPs) using naringin and naringenin as bioreductants.
• To evaluate the biological activities of the synthesized AgNPs.

Main Methods:

• Green synthesis of AgNPs using NG and NGN.
• Characterization via UV-Vis, DLS, STEM, EDX, and FTIR.
• Biological evaluation including antioxidant, antimicrobial, and Allium cepa assays.

Main Results:

• Spherical AgNPs (17 nm for AgNG, 20.4 nm for AgNGN) were successfully synthesized.
• Stable colloidal dispersions with negative zeta potentials and low polydispersity indices (PDIs) were observed.
• AgNPs demonstrated significant antioxidant, antimicrobial, and concentration-dependent cytogenetic effects.

Conclusions:

• Flavonoid-mediated synthesis offers an eco-friendly route to stable, bioactive AgNPs.
• Synthesized AgNPs show potential for diverse biological applications.
• The study confirms the efficacy of NG and NGN in producing functional nanomaterials.