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Tomato-Derived Lycopene: From Phytochemistry and Extraction Technologies to Bioavailability and Nutraceutical
Andra-Monica Anghel Ştefan1, Elena Enachi1, Alina-Georgiana Cristea Hohotă1
1Research Centre in the Medical-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunărea de Jos" University, 800008 Galati, Romania.
Tomatoes are rich in lycopene, a compound offering antioxidant and cardioprotective benefits. This review explores lycopene
Area of Science:
- Phytochemistry
- Nutraceuticals
- Food Science
Background:
- Tomatoes (Solanum lycopersicum L.) are a primary dietary source of carotenoids, notably lycopene.
- Lycopene exhibits significant antioxidant, anti-inflammatory, and cardioprotective properties.
- Oxidative stress reduction is a key health benefit linked to lycopene consumption.
Purpose of the Study:
- To review current data on tomato phytochemicals, focusing on lycopene.
- To examine lycopene's biological mechanisms, health benefits, and factors affecting its bioavailability.
- To analyze lycopene-based supplements and discuss advanced extraction/analysis methods.
Main Methods:
- Literature synthesis of recent data on tomato phytochemicals.
- Analysis of factors influencing lycopene bioavailability (thermal processing, food matrix).
- Review of modern extraction (ultrasound, microwave, supercritical-fluid) and analysis (HPLC) techniques.
- Market analysis of lycopene supplements in Romania, Europe, and the US.
Main Results:
- Lycopene's health benefits are linked to its antioxidant and anti-inflammatory actions.
- Thermal processing and food matrix significantly impact lycopene bioavailability.
- Innovative formulations and nanoencapsulation can enhance lycopene stability and absorption.
- Market supplements show variability in composition, standardization, and safety.
Conclusions:
- Lycopene demonstrates potential as a valuable nutraceutical ingredient.
- Further clinical research is necessary to validate therapeutic claims.
- Optimizing delivery systems is crucial for maximizing lycopene's health benefits.
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