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Medical Induction for Mid trimester Abortion: A Hospital-based Descriptive Cross-sectional Study
Jyotshna Sharma1, Sanjeeb Tiwari2, Manoj Pokhrel3
1Department of Obstetrics and Gyanecology, Kathmandu Medical College-Teaching Hospital, Kathmandu, Nepal.
JNMA; Journal of the Nepal Medical Association
|September 10, 2021
Summary
The combination of mifepristone and misoprostol is highly effective for early second-trimester pregnancy termination, with a 92.5% success rate. This medical approach minimizes complications and the need for surgical intervention.
Area of Science:
- Medical research
- Obstetrics and Gynecology
- Pharmacology
Background:
- Second-trimester abortion, defined as pregnancy termination between 13-28 weeks gestation, is further categorized into early (13-22 weeks) and late (23-28 weeks).
- This study focuses on early second-trimester terminations.
Purpose of the Study:
- To evaluate the efficacy of mifepristone and misoprostol combination for medical induction in early second-trimester abortions.
- To determine the median time to expulsion, complication rates, and the necessity of dilation and evacuation (D&E).
- To review existing literature on mid-trimester abortion efficacy and complications, providing evidence-based recommendations for safe termination regimens.
Main Methods:
- A hospital-based, descriptive cross-sectional study involving 40 pregnant women undergoing second-trimester termination (13-22 weeks).
- Data collected over six months at Kathmandu Medical College Teaching Hospital.
- Convenient sampling was employed after obtaining ethical approval.
Main Results:
- Out of 40 women, 37 (92.5%) achieved successful medical termination.
- Only 3 women (7.5%) required subsequent dilation and evacuation.
Conclusions:
- The combination of mifepristone and misoprostol demonstrates excellent efficacy for pregnancy termination in the early second trimester.
- Appropriate patient evaluation and use of this regimen result in minimal complications.
