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Updated: Oct 20, 2025
Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells
Published on: August 1, 2020
In Vitro 3D Mechanical Stimulation to Tendon-Derived Stem Cells by Bioreactor
Ziming Chen1, Peilin Chen1, Rui Ruan1
1Centre for Orthopaedic Translational Research, Medical School, University of Western Australia, Nedlands, WA, Australia.
Abstract:
Bioreactors can offer an advanced platform to provide conditions that mimic the native microenvironment, which can also provide stretching environment for mechanobiology research. Tendon-derived stem cells (TDSCs) are a type of mechanosensitive and multipotent cells, which behave differently in diverse mechanical stretching environments. We have proved the in vitro three-dimensional (3D) mechanical stimulation could closely mimic the stretching environment in vivo. Thus, here we describe applying a customized bioreactor to provide 3D force for mechanical stimulation on TDSC in vitro.
