Tumor to Tumor Metastasis: A Case Report

Area of Science:

• Oncology
• Gynecologic Pathology
• Surgical Pathology

Background:

• Colon carcinoma commonly metastasizes locally and distantly through hematogenous or lymphatic routes.
• Metastasis to the female genital tract is rare, with limited reports involving uterine leiomyomas.

Observation:

• A 27-year-old female with sigmoid colon adenocarcinoma presented with abdominal pain, bilateral adnexal masses, and vaginal bleeding.
• Surgical exploration revealed metastatic adenocarcinoma in both ovaries and a submucosal leiomyoma.

Findings:

• Histopathology confirmed metastatic adenocarcinoma in the bilateral ovaries.
• The case demonstrated an unusual metastasis from colon cancer to a uterine leiomyoma.

Implications:

• This case underscores the rare phenomenon of tumor-to-tumor metastasis from colon adenocarcinoma to a benign uterine leiomyoma.
• Careful histopathological evaluation of dimorphic lesions is crucial to identify malignant-to-benign tumor-to-tumor metastasis.