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Updated: Oct 20, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

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Restoring order at the cell cycle border: Co-targeting CDK4/6 and CDK2

Rinath Jeselsohn1, Rachel Schiff2, Albert Grinshpun3

  • 1Breast Oncology Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA; Division of Molecular and Cellular Oncology, Dana Farber Cancer Institute, Boston, MA, USA; Center for Functional Cancer Epigenetics, Dana Farber Cancer Institute, Boston, MA, USA.

Cancer Cell
|September 10, 2021
PubMed
Summary

Resistance to CDK4/6 inhibitors is a challenge. A new study identifies cyclin E-CDK2 and Myc signaling as key resistance pathways and introduces a novel CDK2/4/6 inhibitor.

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