Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

70
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
70
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.5K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.5K
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

96
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
96
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

12.4K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
12.4K
Nociception01:44

Nociception

30.9K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
30.9K
Pain01:20

Pain

867
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
867

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of gabapentin on ongoing behaviors displayed by mice with chemotherapy neuropathy.

bioRxiv : the preprint server for biology·2026
Same author

Dyslipidemia is a metabolic hallmark of acute pain in sickle cell disease.

medRxiv : the preprint server for health sciences·2026
Same author

Research recommendations for the HEAL Initiative: A path forward for pain research.

The journal of pain·2026
Same author

A stress-induced PI3P complex controls autophagy in erythroid precursors.

iScience·2026
Same author

Clonazepam activates the transient receptor potential melastatin 8 (TRPM8) ion channel.

bioRxiv : the preprint server for biology·2026
Same author

Not Just Neurons: Pain Is Orchestrated in Partnership with Many Non-neuronal Cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Related Experiment Video

Updated: Oct 20, 2025

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
11:22

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

Published on: April 29, 2013

13.3K

Cutaneous pain in disorders affecting peripheral nerves.

Cheryl L Stucky1, Alexander R Mikesell1

  • 1Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States.

Neuroscience Letters
|September 10, 2021
PubMed
Summary

This review explores how skin pain perception (cutaneous nociception) changes in peripheral neuropathies caused by disease or genetics. It highlights new research on skin cells and potential treatments for chronic pain.

Keywords:
CutaneousKeratinocytesNeuropathic painNeuropathyNociceptorSkin

More Related Videos

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

9.7K
Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

19.9K

Related Experiment Videos

Last Updated: Oct 20, 2025

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
11:22

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

Published on: April 29, 2013

13.3K
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

9.7K
Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

19.9K

Area of Science:

  • Neuroscience
  • Dermatology
  • Pain Research

Background:

  • Acute pain is protective, but chronic pain and allodynia (sensitivity to touch) severely reduce quality of life.
  • Peripheral neuropathic pain results from damage to peripheral sensory neurons, caused by factors like diabetes, chemotherapy, or genetic conditions.
  • Many neuropathies affect the skin, altering cutaneous nociception.

Purpose of the Study:

  • To review how cutaneous nociception is altered in acquired and hereditary peripheral neuropathies.
  • To discuss the molecular mechanisms of noxious stimuli detection and encoding in the skin.
  • To highlight emerging research on non-neuronal skin cells in pain and novel therapeutic opportunities.

Main Methods:

  • Review of existing literature on cutaneous nociception and peripheral neuropathies.
  • Overview of molecular transducers and afferent pathways involved in skin pain signaling.
  • Discussion of clinical manifestations, patient symptoms, and cellular alterations in various neuropathies.

Main Results:

  • Peripheral neuropathies significantly alter skin pain perception, leading to chronic pain or loss of sensation.
  • Both acquired (e.g., diabetic neuropathy) and hereditary (e.g., Charcot-Marie-Tooth) conditions impact cutaneous afferents.
  • Non-neuronal skin cells, like keratinocytes, play a role in cutaneous nociception and neuropathic pain.

Conclusions:

  • Understanding altered cutaneous nociception in peripheral neuropathies is crucial for patient care.
  • New research implicates skin cells in pain mechanisms, offering potential for targeted therapies.
  • Future directions include developing novel cutaneous therapeutics with fewer central nervous system side effects.