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Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain

Tao Xiao1, Luxin Sun1, Min Zhang1

  • 1Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States.

Bioorganic & Medicinal Chemistry Letters
|September 10, 2021
PubMed

Keywords:
GRB2InhibitorsMacrocyclic peptidesProtein-Protein InteractionRas-MAPK signalingSH2 domainsX-ray crystallography

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