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Association of chronic venous disease with major adverse cardiovascular events

Tejas P Singh1, Ramesh B Velu2, Frank Quigley3

  • 1Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia; The Department of Vascular and Endovascular Surgery, Townsville University Hospital, Townsville, Queensland, Australia.

Journal of Vascular Surgery. Venous and Lymphatic Disorders
|September 10, 2021
PubMed

Insights

Severe chronic venous disease (CVD) significantly increases the risk of major adverse cardiovascular events (MACE), including heart attack, stroke, or cardiovascular death. This finding highlights the importance of managing CVD to mitigate cardiovascular risks.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Surgery
  • Epidemiology

Background:

  • Chronic venous disease (CVD) is a common condition affecting leg veins.
  • The association between CVD severity and major adverse cardiovascular events (MACE) requires further investigation.

Purpose of the Study:

  • To determine if severe chronic venous disease (CVD) is linked to a higher risk of major adverse cardiovascular events (MACE) compared to mild CVD.

Main Methods:

  • Prospective recruitment of 774 participants with CVD from Australian vascular departments.
  • CVD severity assessed using the CEAP classification; MACE identified through follow-up and medical records.
  • Kaplan-Meier and Cox proportional hazard analyses used to assess the association between CVD severity and MACE.

Main Results:

  • Participants with severe CVD (CEAP C5-C6) showed a significantly increased risk of MACE compared to those with mild CVD (CEAP C2-C4).
  • Specifically, C6 CVD cases had a threefold greater risk of MACE (HR 3.03) versus C2 CVD cases.
  • Adjusted analyses revealed an overall increased MACE risk for severe CVD (aHR 2.37).

Conclusions:

  • Severe CVD independently elevates MACE risk, irrespective of traditional cardiovascular risk factors.
  • The findings underscore the need for proactive cardiovascular risk assessment in patients with severe CVD.
  • Further research is warranted to elucidate the underlying mechanisms driving this increased cardiovascular risk.
Abstract

Keywords:
Chronic venous diseaseMajor adverse cardiovascular eventsVenous ulcer

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