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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

11
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
11
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

12
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
12
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

17
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
17
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

12
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

9
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
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Related Experiment Video

Updated: Jul 19, 2025

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Recent developments in targets for ischemic foot disease.

Jonathan Golledge1,2,3, Shivshankar Thanigaimani1,3, Kristen S Barratt1,3

  • 1Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia.

Diabetes/Metabolism Research and Reviews
|August 11, 2023
PubMed
Summary

Novel medical therapies are being explored to treat ischaemic foot disease, a complication of diabetes. Research in animal models and clinical trials identifies new targets to improve blood flow and healing, aiming for broader therapeutic applications.

Keywords:
clinical trialsdiabetes-related foot diseaseischaemiamouse modelsperipheral artery diseaseulcer

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Area of Science:

  • Vascular Biology and Regenerative Medicine
  • Diabetology and Metabolic Diseases

Background:

  • Diabetes significantly increases the risk of ischaemic foot disease, leading to severe complications like amputation.
  • Current revascularisation treatments have limitations, with many patients being unsuitable for surgery or experiencing treatment failure.

Purpose of the Study:

  • To review recent research on novel medical targets for treating limb ischaemia, focusing on potential therapeutic strategies beyond traditional revascularisation.
  • To explore findings from animal models and clinical trials investigating new approaches for improving blood supply and wound healing in ischaemic limbs.

Main Methods:

  • Analysis of pre-clinical research in animal models identifying molecular targets (e.g., CD34+ progenitor cells, specific microRNAs, signaling pathways).
  • Review of randomized controlled trials testing novel medical therapies, including growth factors, cell-based therapies, and pharmacological agents.
  • Evaluation of challenges in translating animal model findings to human clinical applications.

Main Results:

  • Animal models suggest targeting CD34+ cell mobilization, specific microRNAs (miR-181, miR-130b), and pathways like Wingless can enhance vascular recovery.
  • Pharmacological agents such as soluble guanylate cyclase stimulators (riociguat, praliciguat) and trimetazidine showed promise in promoting blood flow recovery.
  • Early clinical trials with hepatocyte growth factor plasmids and bone marrow-derived cells indicate potential, though scalability remains a concern.

Conclusions:

  • An increasing number of potential targets for medical revascularisation are being identified through ongoing research.
  • Further investigation and larger clinical trials are necessary to translate these promising findings into broadly applicable therapies for ischaemic foot disease.