Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cell Cycle Control System02:11

The Cell Cycle Control System

12.9K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
12.9K
What is the Cell Cycle?00:56

What is the Cell Cycle?

7.9K
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the...
7.9K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

3.4K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.4K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

5.1K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.1K
Negative Regulator Molecules01:23

Negative Regulator Molecules

36.7K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
36.7K
Positive Regulator Molecules02:39

Positive Regulator Molecules

5.8K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HIV-1 signalling remodels nuclear pores to licence infection.

Nature·2026
Same author

Ras signalling at the actin cortex: Coordinating local and global changes to cell morphology.

Current opinion in cell biology·2025
Same author

Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner.

Nature communications·2024
Same author

Oncogenic Ras deregulates cell-substrate interactions during mitotic rounding and respreading to alter cell division orientation.

Current biology : CB·2023
Same author

The role of RAS oncogenes in controlling epithelial mechanics.

Trends in cell biology·2022
Same author

Vaccinia Virus Arrests and Shifts the Cell Cycle.

Viruses·2022
Same journal

Regulation and function of specialized membrane protrusions in intercellular communication.

Nature reviews. Molecular cell biology·2026
Same journal

Tight junction structure, assembly and (dys)function.

Nature reviews. Molecular cell biology·2026
Same journal

Caveolae mechanics in cellular functions and disease.

Nature reviews. Molecular cell biology·2026
Same journal

Principles and mechanisms of plant acclimation to heat stress.

Nature reviews. Molecular cell biology·2026
Same journal

Elucidating structure-function relationships in the mammalian nucleolus.

Nature reviews. Molecular cell biology·2026
Same journal

New developments and applications of human organoids.

Nature reviews. Molecular cell biology·2026
See all related articles

Related Experiment Video

Updated: Oct 20, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

27.8K

Cell cycle control in cancer.

Helen K Matthews1,2, Cosetta Bertoli1, Robertus A M de Bruin3,4

  • 1MRC Laboratory for Molecular Cell Biology, University College London, London, UK.

Nature Reviews. Molecular Cell Biology
|September 11, 2021
PubMed
Summary
This summary is machine-generated.

Cancer cells divide uncontrollably due to cell cycle disruptions. Understanding these cell cycle control mechanisms reveals new therapeutic strategies for cancer treatment.

More Related Videos

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

19.6K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K

Related Experiment Videos

Last Updated: Oct 20, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

27.8K
Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
08:52

Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

19.6K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K

Area of Science:

  • Oncology
  • Cell Biology
  • Genetics

Background:

  • Cancer is characterized by uncontrolled cell division.
  • Cell division is regulated by conserved cell cycle control mechanisms.
  • Cell cycle checkpoints act as DNA surveillance to prevent genetic errors.

Purpose of the Study:

  • To explore cell cycle control mechanisms in cancer.
  • To identify how cancer-associated mutations affect cell cycle regulation.
  • To reveal how cell cycle dependencies can be exploited for cancer therapy.

Main Methods:

  • Review of cell cycle control mechanisms.
  • Analysis of cancer-associated mutations impacting cell cycle regulation.
  • Examination of cell cycle checkpoint functions.

Main Results:

  • Mutations perturbing cell cycle control allow continuous division by impairing cell cycle exit.
  • Continuous cell division increases reliance on other cell cycle mechanisms for viability.
  • Detailed insights into cell cycle regulation in cancer have been elucidated.

Conclusions:

  • Compromised cell cycle exit is a hallmark of cancer.
  • Cancer cells develop dependencies on remaining cell cycle controls.
  • Exploiting these dependencies offers promising avenues for novel cancer treatments.