Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated

Although deep inspiratory breath-hold (DIBH) is routinely used for left-sided breast cancers, its benefits for right-sided breast cancer (rBC) have yet to be established. We compared free-breathing (FB) and DIBH treatment plans for a cohort of rBC undergoing regional nodal irradiation (RNI) to determine its potential benefits.

rBC patients considered for RNI (internal mammary nodal chains, supraclavicular field, with or without axilla) from October 2017 to May 2020 were included in this analysis. For each patient, FB versus DIBH plans were generated and dose volume histograms evaluated the following parameters: mean lung dose, ipsilateral lung V₂₀/V₅ (volumes of lung receiving 20 Gy and 5 Gy, respectively); mean heart dose and heart V₅ (volumes of heart receiving 5 Gy); liver V_{20 absolute} /V_{30 absolute} (absolute volume of liver receiving 20 Gy and 30 Gy, respectively), liver D_max, and total liver volume irradiated (TVI_liver). The dosimetric parameters were compared using Wilcoxon signed-rank testing.

Fifty-four patients were eligible for analysis, comparing 108 FB and DIBH plans. DIBH significantly decreased all lung and liver parameters: mean lung dose (19.7 Gy-16.2 Gy, P < .001), lung V₂₀ (40.7%-31.7%, P < .001), lung V₅ (61.2%-54.5%, P < .001), TVI_liver (1446 cc vs 1264 cc; P = .006) liver D_max (50.2 Gy vs 48.9 Gy; P = .023), liver V₂₀ (78.8-23.9 cc, P < .001), and liver V₃₀ (58.1-14.6 cc, P < .001) compared with FB. DIBH use did not significantly improve heart parameters, although the V_5Heart trended on significance (1.25-0.6, P = .067).

This is the largest cohort to date analyzing DIBH for RNI-rBC. Our findings demonstrate significant improvement in all lung and liver parameters with DIBH, supporting its routine consideration for rBC patients undergoing comprehensive RNI.