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Pseudoporphyria from nonsteroidal antiinflammatory drugs
1Department of Dermatology, Waikato Hospital, Hamilton.
The New Zealand Medical Journal
|May 27, 1987
Summary
Drug-induced pseudoporphyria, characterized by skin blistering with normal porphyrin levels, can be caused by medications like naproxen. This study reports eight cases linked to naproxen and instances involving ketoprofen and diflunisal.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Pseudoporphyria presents with skin fragility and blistering, mimicking cutaneous porphyria.
- Crucially, pseudoporphyria is defined by normal porphyrin metabolism, distinguishing it from true porphyrias.
Purpose of the Study:
- To investigate and report cases of drug-induced pseudoporphyria.
- To identify specific medications associated with this condition.
Main Methods:
- Case series reporting clinical observations.
- Review of patient data associated with specific drug exposures.
Main Results:
- Eight cases of drug-induced pseudoporphyria linked to naproxen are presented.
- Additional cases associated with ketoprofen and diflunisal are also reported.
Conclusions:
- Naproxen is identified as a potential cause of drug-induced pseudoporphyria.
- Ketoprofen and diflunisal may also induce pseudoporphyria, highlighting the need for awareness among clinicians.