Cognitive impairment in children with benign childhood epilepsy with centrotemporal spikes and attention deficit
Hai-Bo Fang1, Rong Wang1, Lin-Na Chu1
1Department of Pediatrics, Cangzhou People's Hospital, Cangzhou, Hebei 061000, China.
Insights
Children with both benign childhood epilepsy with centrotemporal spikes (BECT) and attention deficit hyperactivity disorder (ADHD) exhibit similar cognitive impairment fields as those with either condition alone, but with greater severity in certain areas.
Area of Science:
- Neuroscience
- Pediatric Neurology
- Cognitive Psychology
Background:
- Benign childhood epilepsy with centrotemporal spikes (BECT) and attention deficit hyperactivity disorder (ADHD) are common neurodevelopmental disorders in children.
- Co-occurrence of BECT and ADHD may lead to distinct cognitive profiles.
- Understanding these differences is crucial for targeted interventions.
Purpose of the Study:
- To investigate and compare cognitive impairment in children with co-occurring BECT and ADHD versus those with BECT or ADHD alone.
- To identify specific cognitive domains affected by the combined conditions.
Main Methods:
- A prospective study involving children newly diagnosed with BECT and ADHD (n=80), BECT alone (n=91), ADHD alone (n=70), and healthy controls (n=70).
- Cognitive function assessed using event-related potential P300, Wechsler Intelligence Scale for Children, and integrated visual and auditory continuous performance tests.
Main Results:
- Children with BECT+ADHD, BECT alone, and ADHD alone showed significantly prolonged P300 latency and reduced P300 amplitude compared to controls.
- All patient groups exhibited significant reductions in various cognitive scores, including intelligence quotients and attention measures.
- The BECT+ADHD group demonstrated more severe cognitive impairments in several domains compared to children with BECT or ADHD individually.
Conclusions:
- Combined BECT and ADHD in children results in cognitive impairment comparable in scope but greater in severity to that seen in each condition alone.
- This highlights the significant impact of comorbid neurodevelopmental disorders on cognitive function.
Objectives:
To study the difference in cognitive impairment between the children with benign childhood epilepsy with centrotemporal spikes (BECT) and attention deficit hyperactivity disorder (ADHD) and those with BECT or ADHD alone.
Methods:
A prospective study was performed on 80 children with BECT and ADHD, 91 children with BECT, and 70 children with ADHD , who were diagnosed with the diseases for the first time. Seventy children of the same age who underwent physical examination were enrolled as the healthy control group. Event-related potential P300, Wechsler Intelligence Scale for Children, and integrated visual and auditory continuous performance test were used to measure and compare each index between groups.
Results:
Compared with the healthy control group, the BECT+ADHD group, the BECT group, and the ADHD group had a significantly prolonged P300 latency, a significant reduction in the amplitude of P300, and significant reductions in the scores of verbal comprehension index (VCI), perceptual reasoning index (PRI), working memory index (WMI), processing speed index (PSI), full scale intelligence quotient (FSIQ), auditory response control quotient (ARCQ), visual response control quotient, full response control quotient (FRCQ), auditory attention quotient (AAQ), visual attention quotient, and full attention quotient (P<0.05). Compared with the BECT group, the BECT+ADHD group had a significantly prolonged P300 latency, a significant reduction in the amplitude of P300, and significant reductions in the scores of VCI, PRI, WMI, PSI, FSIQ, and FRCQ (P<0.05). Compared with the ADHD group, the BECT+ADHD group had a significantly prolonged P300 latency, a significant reduction in the amplitude of P300, and significant reductions in the scores of VCI, PRI, FSIQ, ARCQ, FRCQ, and AAQ (P<0.05).
Conclusions:
Compared with the children with BECT or ADHD alone, the children with both BECT and ADHD have basically the same fields of cognitive impairment but a higher degree of cognitive impairment in some fields.
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