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Time-dependent Diffusion in Brain Abscesses Investigated with Oscillating-gradient Spin-echo.

Tomoko Maekawa¹, Masaaki Hori^1,2, Katsutoshi Murata³

¹Department of Radiology, Juntendo University School of Medicine.

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine

|September 13, 2021

Summary

This summary is machine-generated.

Apparent diffusion coefficient (ADC) values in brain abscesses are higher with short diffusion times than long ones. This diffusion time dependence suggests restricted diffusion and viscosity within the lesions, offering insights into internal structures.

Keywords:

brain abscess diffusion time diffusion-weighted imaging microstructure oscillating-gradient spin-echo

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Area of Science:

Magnetic Resonance Imaging
Neuroimaging
Biophysics

Background:

Oscillating-gradient spin-echo sequences are valuable for measuring diffusion weighting.
These sequences can offer insights into the internal structures of biological tissues.

Purpose of the Study:

To investigate the diffusion time dependence of apparent diffusion coefficient (ADC) values in brain abscesses.
To explore the relationship between ADC values, diffusion time, and internal lesion characteristics.

Main Methods:

Utilized oscillating-gradient spin-echo sequences to acquire diffusion-weighted images.
Measured apparent diffusion coefficient (ADC) values at varying diffusion times.
Analyzed two cases of brain abscess.

Main Results:

Observed higher ADC values at short diffusion times compared to long diffusion times in brain abscesses.
Demonstrated a diffusion time dependence of ADC in the studied lesions.

Conclusions:

Diffusion time dependence of ADC in brain abscesses indicates contributions from both substrate viscosity and restricted diffusion.
The findings suggest that internal structures within brain abscesses influence water diffusion characteristics.