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Christian Bär1,2, Anselm A Derda1,3, Thomas Thum1,2,4

  • 1Institut für Molekulare und Translationale Therapiestrategien, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, Deutschland.

Biospektrum : Zeitschrift Der Gesellschaft Fur Biologishe Chemie (GBCH) Und Der Vereinigung Fur Allgemeine Und Angewandte Mikrobiologie (VAAM)
|September 13, 2021
PubMed
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Despite rapid COVID-19 vaccine development, effective treatments for infected individuals are lacking. MicroRNAs show promise as therapeutic targets and diagnostic biomarkers for COVID-19 and long COVID.

Area of Science:

  • Molecular Biology
  • Genetics
  • Infectious Diseases

Context:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a significant global health challenge.
  • While vaccines prevent infection, effective treatments for active COVID-19 remain limited.
  • MicroRNAs (miRNAs) are key regulators of gene expression with established roles in disease pathogenesis.

Purpose:

  • To highlight the therapeutic potential of microRNAs in treating COVID-19.
  • To underscore the utility of microRNAs as diagnostic and prognostic biomarkers for COVID-19 and its sequelae, such as long COVID.

Summary:

  • MicroRNAs are small non-coding RNAs that regulate gene expression and are implicated in various biological processes.
  • Research is exploring microRNAs as potential therapeutic agents, with some already in clinical trials.

Related Experiment Videos

  • Circulating microRNAs offer a promising avenue for non-invasive diagnosis and prognosis of COVID-19 and persistent symptoms.

    • Impact:

    • MicroRNA-based therapies could provide novel treatment options for COVID-19 patients.
    • Detection of specific microRNAs in bodily fluids may enable early diagnosis and monitoring of disease progression and long COVID.
    • This research contributes to the development of advanced strategies for managing the ongoing COVID-19 pandemic.