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Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
Published on: February 24, 2016
Collost Bioplastic Collagen Material for the Treatment of Burns
L I Budkevich1, G V Mirzoyan2, R B Gabitov3
1Professor, Chief Researcher, Department of Combustiology and Reconstructive Plastic Surgery, Research Institute of Pediatric Surgery, Pirogov Russian National Research Medical University, 1 Ostrovitianova St., Moscow, 117997, Russia; Head of the Burn Center, Children's City Clinical Hospital No.9 named after G.N. Speransky, 29 Shmitovskiy Proezd, Moscow, 123317, Russia; Head of the 2 Burn Unit, Children's City Clinical Hospital No.9 named after G.N. Speransky, 29 Shmitovskiy Proezd, Moscow, 123317, Russia.
Abstract:
The aim of the study was to evaluate the efficacy and safety of the Collost bioplastic material in the treatment of borderline and mosaic burns.
Materials And Methods:
We conducted a prospective multicenter study, which included 94 patients aged 1 to 12 years with thermal skin burns (grade II-III by ICD-10). Patients were divided into four groups. In groups 1-3, various forms of the Collost bioplastic material were used (group 1 - 7% gel, group 2 - membranes, group 3 - powder) in combination with hydrocolloid dressings containing Ag+ ions. Patients of the control group (group 4) underwent the traditional local conservative treatment using hydrocolloid dressings alone. Concomitant therapy was similar in all of the participating centers. The total follow-up period was 4 weeks from the date of burn injury.
Results:
On day 14, there were 23 cases (92%) of complete epithelization in group 1, 13 cases (68.4%) - in group 2, 21 cases (78%) - in group 3, and 9 cases (39.1%) - in group 4. The data from groups 1 and 3 significantly differed from those in control (p<0.05). The epithelialization of the burned skin in the Collost groups (7% gel and powder) was on average one week faster compared to the control.
Conclusion:
The Collost bioplastic material (in the form of gel or powder) in combination with hydrocolloid dressings can be a functional and inexpensive alternative to autografts in the treatment of borderline and mosaic burns.
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