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Related Experiment Video

Updated: Oct 20, 2025

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Framework for quantitative three-dimensional choroidal vasculature analysis using optical coherence tomography.

Ashish Saxena^1,2, Xinwen Yao^1,2,3, Damon Wong^1,2,3

¹Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Biomedical Optics Express

|September 13, 2021

Summary

This summary is machine-generated.

A new framework accurately quantifies choroidal vasculature using swept-source optical coherence tomography (OCT). This method reveals significantly reduced choroidal vessel volume in high myopia eyes, aiding in understanding retinal disease pathogenesis.

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Doppler Optical Coherence Tomography of Retinal Circulation

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Published on: September 18, 2012

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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Area of Science:

Ophthalmology
Medical Imaging
Vascular Biology

Background:

Choroidal vasculature is crucial in retinal diseases like myopic maculopathy and age-related macular degeneration.
Current optical coherence tomography (OCT) struggles with quantitative choroidal vascular analysis.

Purpose of the Study:

To develop and validate a novel framework for segmenting and quantifying choroidal vasculature using swept-source OCT.
To assess differences in choroidal vascular volume between healthy and highly myopic eyes.

Main Methods:

A prototype swept-source OCT (PLEX Elite 9000) was used with a 3x3 mm macular scan protocol.
A framework was developed to automatically segment choroidal vessels from reconstructed enface OCT images.
Segmentation accuracy was validated against manual annotations and assessed for repeatability.

Main Results:

The proposed framework achieved high segmentation accuracy (96% ± 1%) and repeatability (Dice coefficient 0.83 ± 0.04).
A significant decrease in choroidal vessel volume was observed in highly myopic eyes compared to controls (p<0.001).

Conclusions:

The validated framework enables accurate and repeatable quantification of choroidal vasculature from swept-source OCT data.
Reduced choroidal vessel volume is a key characteristic of high myopia, suggesting its role in disease pathogenesis.