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Updated: Oct 20, 2025
Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
Published on: May 2, 2017
Liver: glucose metabolism and 18F-fluorodeoxyglucose PET findings in normal parenchyma and diseases
Ismet Sarikaya1, Jan-Henning Schierz2, Ali Sarikaya3
1Department of Nuclear Medicine, Kuwait University Faculty of Medicine Safat, Kuwait.
Abstract:
Liver has a complex and unique energy metabolism and plays a major role in glucose homeostasis. Liver is the main control center for glycogenesis, glycogenolysis, glycolysis and gluconeogenesis which are essential to provide energy for other tissues. Liver meets its own energy need from various sources which is mainly glucose in the fed state and fatty acids in the fasting state. In this review article, we will mainly describe the glucose metabolism of the liver, effect of various factors on 18F-fluorodeoxyglucose (FDG) activity/uptake in the normal liver and 18F- FDG positron emission tomography (PET) uptake patterns in various malignant and benign liver pathologies. Brief information on metabolomics profiling analyses in liver disorders will also be provided.
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