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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
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Integrated Bioinformatics-Based Identification of Potential Diagnostic Biomarkers Associated with Diabetic Foot Ulcer
Long Qian1, Zhipeng Xia2, Ming Zhang1
1Department of Hand Surgery, Wuhan Fourth Hospital; Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, China.
Journal of Diabetes Research
|September 13, 2021
Summary
This study identified key genes linked to diabetic foot ulcers (DFU) by analyzing gene expression data. These findings may help develop new treatments for DFU patients.
Area of Science:
- Biomolecular research
- Genomics
- Bioinformatics
Background:
- Diabetic foot ulcer (DFU) poses a significant clinical challenge.
- Identifying biomarkers for DFU is crucial for developing effective treatments.
Purpose of the Study:
- To detect potential biomarkers associated with diabetic foot ulcer (DFU) incidence.
- To identify key hub genes involved in DFU development.
Main Methods:
- Downloaded and analyzed gene expression datasets (GSE7014, GSE29221) from the Gene Expression Omnibus (GEO) database.
- Identified differentially expressed genes (DEGs) between DFU and healthy samples.
- Performed protein-protein interaction (PPI) network construction, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and Gene Ontology (GO) enrichment analyses.
Main Results:
- Identified 1192 DEGs in GSE7014 (900 upregulated, 292 downregulated) and 1177 DEGs in GSE29221 (257 upregulated, 919 downregulated).
- GO analyses revealed enrichment in biological processes like sarcomere organization and muscle filament sliding.
- KEGG pathway analysis highlighted enrichment in adrenergic signaling in cardiomyocytes, dilated cardiomyopathy, and tight junction pathways.
Conclusions:
- Bioinformatic analyses successfully identified key hub genes associated with DFU development.
- These identified genes represent potential biomarkers for DFU.
- The findings provide a foundation for novel therapeutic strategies for diabetic foot ulcers.
