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Brazil Nut Supplementation Does Not Regulate PPARβ/δ Signaling Pathway in Peripheral Blood Mononuclear Cells from

Beatriz Oliveira da Cruz1,2, Ludmila Ferreira Medeiros de Cardozo1,2, Karen Salve Coutinho-Wolino2,3

  • 1Graduate Program in Cardiovascular Sciences, Universidade Federal Fluminense, Niterói, Brazil.

Journal of the American Nutrition Association
|September 13, 2021
PubMed

Insights

Daily Brazil nut supplementation did not alter PPARβ/δ mRNA expression in coronary artery disease patients. This study found no significant changes in inflammation or oxidative stress markers after three months of consuming one Brazil nut daily.

Area of Science:

  • Nutritional Biochemistry
  • Cardiovascular Research
  • Molecular Biology

Background:

  • Peroxisome proliferator-activated receptor (PPAR)β/δ activation is a key target for managing inflammation in cardiovascular disease.
  • Brazil nuts, rich in selenium and unsaturated fatty acids, may influence PPARβ/δ due to their anti-inflammatory and antioxidant properties.
  • Understanding natural ligands for PPARβ/δ is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To investigate the effect of daily Brazil nut supplementation on PPARβ/δ mRNA expression in patients with Coronary Artery Disease (CAD).
  • To assess potential changes in inflammatory and oxidative stress biomarkers associated with PPARβ/δ activity.

Main Methods:

  • A secondary analysis of a 3-month randomized controlled trial involving 36 CAD patients.
  • Patients were assigned to consume one Brazil nut daily or a control group with no intervention.
  • Gene expression (PPARβ/δ, NF-κB) and biochemical parameters were analyzed at baseline and after intervention.

Main Results:

  • One Brazil nut daily for three months did not significantly alter PPARβ/δ mRNA expression (p=0.178) or NF-κB mRNA expression (p=0.554).
  • No significant changes were observed in other biochemical parameters related to inflammation and oxidative stress in either group.

Conclusions:

  • Supplementation with one Brazil nut per day for three months is insufficient to upregulate PPARβ/δ expression in CAD patients.
  • Further research is needed to explore the potential of Brazil nuts or other natural compounds in modulating inflammatory pathways in cardiovascular disease.

Keywords:
Brazil nutsCoronary artery diseasePPAR betaPPAR deltabertholletia

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