Related Experiment Video
Updated: Jun 17, 2026

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
Published on: November 21, 2025
Renal expression of Bach1 and oxidative stress in chronic kidney disease: evidence from a preclinical model
Beatriz Oliveira Da Cruz1, Patricia Pereira Almeida2, Nathalia Silva-Costa1
1Universidade Federal Fluminense, Programa de Pós-Graduação em Ciências Cardiovasculares, Niterói, RJ, Brazil.
Introduction:
The transcription factor BTB and CNC homology 1 (Bach1) represses the nuclear factor erythroid 2-related factor 2 (Nrf2), which controls antioxidant gene expression, and its role in chronic kidney disease (CKD) remains unclear.
Methods:
CKD was induced by 5/6 nephrectomy in rats. Kidney fibrosis and oxidative stress markers were measured. The gene expression of Nrf2, Bach1, and nuclear factor kappa B (NF-κB) was assessed.
Results:
CKD increased oxidative stress markers in plasma, kidney, and heart, as well as promoted kidney fibrosis. Moreover, CKD reduced cardiac Nrf2 expression. However, Bach1, Nrf2, and NF-κB remained unchanged in the kidney.
Conclusion:
CKD did not modulate Bach1 mRNA levels in the kidneys of 5/6 nephrectomized rats.
Related Concept Videos
Chronic Kidney Disease I: Introduction
Chronic Kidney Disease II: Clinical Manifestations
Acute Kidney Injury II: Pathophysiology
Chronic Kidney Disease III: Interprofessional Care

