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Published on: May 9, 2013
White Matter Hyperintensity Burden and Collateral Circulation in Large Vessel Occlusion Stroke
Imad Derraz1, Mohamed Abdelrady1, Nicolas Gaillard2
1Department of Neuroradiology (I.D., M.A., R.A., F.C., C.D., P.-H.L., C.R., G.G., A.B., V.C.), Hôpital Gui de Chauliac, Montpellier University Medical Center, Montpellier, France.
White matter hyperintensity (WMH) burden did not show a significant association with leptomeningeal collateral status in patients undergoing endovascular thrombectomy for acute ischemic stroke. This finding suggests WMH does not influence collateral recruitment in large vessel occlusive stroke.
Area of Science:
- Neurology
- Radiology
- Vascular Medicine
Background:
- White matter hyperintensity (WMH) is a marker of chronic cerebral small vessel disease.
- WMH may influence the development of leptomeningeal collaterals.
Purpose of the Study:
- To investigate the association between WMH burden and collateral circulation.
- To assess WMH impact in patients with anterior circulation acute ischemic stroke treated with endovascular thrombectomy.
Main Methods:
- Included 302 patients with acute ischemic stroke treated via endovascular thrombectomy.
- Assessed WMH volumes using semiautomated volumetric analysis on MRI.
- Graded collateral status on baseline angiography using a standardized system.
Main Results:
- 49.3% of patients had poor collaterals.
- Median total WMH volume was 3.76 cm³.
- No significant relationship was found between WMH burden and collateral status (aOR 0.987; P=0.12).
Conclusions:
- WMH burden does not appear to be overtly associated with collateral status.
- This finding is relevant for large vessel occlusive stroke treated with thrombectomy.
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