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Thyroid function in fasting rats: variations in 131I uptake and transient decrease in peroxidase activity.

E G Moura1, C F Ramos, C C Nascimento

  • 1Laboratório de Fisiologia Endócrina, Universidade do Estado do Rio de Janeiro, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|January 1, 1987
PubMed
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Fasting impairs rat thyroid function, decreasing thyroid peroxidase activity and serum thyroid hormones. Thyroid-stimulating hormone (TSH) partially reverses some effects but not all, indicating intrinsic glandular dysfunction during fasting.

Area of Science:

  • Endocrinology
  • Thyroid Physiology
  • Animal Models

Background:

  • Fasting significantly impacts metabolic processes.
  • Thyroid hormones regulate metabolism and energy homeostasis.
  • The effects of fasting on thyroid function, especially under TSH stimulation, require further elucidation.

Purpose of the Study:

  • To investigate the impact of fasting on rat thyroid function.
  • To assess the role of TSH in mitigating fasting-induced changes in thyroid activity.
  • To determine if TSH can fully restore thyroid function during fasting.

Main Methods:

  • Studied serum thyroxine (T4) and triiodothyronine (T3) levels.
  • Measured radioiodide thyroid uptake at 2 and 24 hours.
  • Assessed thyroid peroxidase (TPO) activity in fasting rats with or without TSH treatment over 2-5 days.

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Main Results:

  • Fasting decreased TPO activity on day 3 in non-TSH treated rats.
  • TSH treatment maintained higher TPO activity compared to controls.
  • Radioiodide uptake showed complex changes, decreasing at 2h (F-) and increasing at 24h (F- and F+).
  • Serum T3 and T4 levels decreased in both fasting groups.

Conclusions:

  • Fasting induces significant alterations in rat thyroid function.
  • TSH administration partially reverses some fasting-induced thyroid changes.
  • Intrinsic impairment of thyroid glandular function during fasting persists despite TSH support.