Related Experiment Video
Updated: Oct 20, 2025
09:23
A Protocol for Detecting and Scavenging Gas-phase Free Radicals in Mainstream Cigarette Smoke
Published on: January 2, 2012
19.6K
Versatile Ti3C2T MXene for free-radical scavenging
Jiang Liu1, Wei Lu1, Xifeng Lu2
1Flexible Printed Electronics Technology Center and School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, 518055 China.
Nano Research
|September 14, 2021
Summary
MXene-Ti3C2Tx nanosheets demonstrate potent free-radical scavenging abilities, protecting cells from oxidative damage. This discovery opens new avenues for MXenes in biomedical applications, particularly in combating free-radical related conditions.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- MXenes are emerging 2D materials with unique properties.
- Their applications are continuously being explored.
- The free-radical scavenging potential of MXenes remains largely uninvestigated.
Purpose of the Study:
- To investigate the free-radical scavenging properties of MXene-Ti3C2Tx nanosheets.
- To elucidate the reaction mechanism between Ti3C2Tx and hydrogen peroxide (H2O2).
- To develop a colorimetric H2O2 strip assay based on Ti3C2Tx.
Main Methods:
- Demonstration of the reaction mechanism and equation between Ti3C2Tx and H2O2.
- Systematic confirmation of Ti3C2Tx's scavenging capability for reactive oxygen species (ROS) and reactive nitrogen species (RNS).
- In vitro assessment of Ti3C2Tx's antioxidant capability using an oxidative damage model in AML-12 cells.
Main Results:
- Ti3C2Tx nanosheets exhibit significant free-radical scavenging activity.
- A colorimetric H2O2 strip assay was successfully designed with good performance.
- Ti3C2Tx demonstrated protective effects against oxidative damage in liver cells.
Conclusions:
- MXene-Ti3C2Tx possesses remarkable antioxidant and free-radical scavenging properties.
- This study highlights the potential of MXenes in FR-related biomedical applications.
- The findings pave the way for novel diagnostic tools and therapeutic strategies involving MXenes.
Related Concept Videos
01:16Radical Reactivity: Nucleophilic Radicals
2.2K
Radicals adjacent to electron-donating groups are called nucleophilic radicals. These radicals readily react with electrophilic alkenes. The SOMO–LUMO interactions are the driving force for the reaction, where the high-energy SOMO of the electron-rich, nucleophilic radicals interacts with the low-energy LUMO of the electron-deficient, electrophilic alkenes. Such SOMO–LUMO interactions are the basis of reactive radical traps, affecting the selectivity in radical reactions. For...
2.2K
01:10Radical Reactivity: Steric Effects
2.0K
The presence of electron-donating, electron-withdrawing, or conjugating groups adjacent to a radical center, imparts electronic stabilization to the radicals. Examples of such electronically-stabilized radicals are triphenylmethyl, tetramethylpiperidine‐N‐oxide, and 2,2‐diphenyl‐1‐picrylhydrazyl. These radicals are remarkably stable and are known as persistent radicals. Some of the persistent radicals can even be isolated and purified.
Along with electronic...
Along with electronic...
2.0K
01:20Radical Autoxidation
2.5K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.5K
01:10Radical Chain-Growth Polymerization: Overview
2.8K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
2.8K
01:11Radical Reactivity: Overview
2.2K
Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
2.2K
01:02Radical Reactivity: Electrophilic Radicals
2.0K
Radicals adjacent to electron‐withdrawing groups are called electrophilic radicals. These radicals readily react with nucleophilic alkenes. For example, the malonate radical, in which the radical center is flanked by two electron‐withdrawing groups, reacts readily with butyl vinyl ether, which consists of an electron‐donating oxygen substituent. The reaction between electrophilic malonate radical and nucleophilic vinyl ether is favored because the radical has a...
2.0K