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A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis
Alexander Walkden1, Mohammed Salem1, Marios Stavrakas1
1Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Plymouth NHS Trust, Plymouth, Devon, United Kingdom.
Significance Statement:
Granulomatosis with polyangitis (GPA) is a systemic necrotizing vasculitis comprising of inflammation of small and medium-sized vessels.1 It typically presents with involvement of the upper and lower airways as well as the kidneys. If left untreated, end-organ damage may occur. Hematological investigations typically demonstrate the presence of antinuclear cytoplasmic antibodies (ANCA).2 Here, we discuss an unusual presentation of ANCA negative GPA, presenting initially with nasal symptoms.
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