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Updated: Oct 20, 2025

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex
Pragati Pandey1, Jitendra K Bera1
1Department of Chemistry and Center for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, India. jbera@iitk.ac.in.
Abstract:
A terminal [Ni-OH] complex 1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst 1 is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of 1 towards amide reduction follows an inverse trend, i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.
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