Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparative effects of repeated sprint training and tempo training on repeated sprint ability and match performance in rugby players.

Scientific reports·2026

Same author

Cross domain consistency of aesthetic preference-driven social behavior.

Frontiers in neural circuits·2026

Same author

Neural signatures of human psychological resilience driven by acute stress.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Differential working memory changes following methylphenidate in medication-naive and medication-experienced adults with ADHD.

PCN reports : psychiatry and clinical neurosciences·2026

Same author

Self-referential judgments from the same personality trait scales show increased representational similarity in mPFC.

Communications psychology·2025

Same author

Differentiation between bipolar disorder and major depressive disorder based on AMPA receptor distribution.

Frontiers in neural circuits·2025

Search research articles

Related Experiment Video

Updated: Oct 20, 2025

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Reversible Fronto-occipitotemporal Signaling Complements Task Encoding and Switching under Ambiguous Cues.

Kaho Tsumura¹, Keita Kosugi¹, Yoshiki Hattori¹

¹Department of Biosciences and Informatics, Keio University, Yokohama 223-0061, Japan.

Cerebral Cortex (New York, N.Y. : 1991)

|September 14, 2021

Summary

Brain signals help us adapt to changing environments. Top-down and bottom-up neural communication in the fronto-occipitotemporal circuit guides behavioral flexibility based on environmental cues.

Keywords:

behavioral flexibility deep neural network occipitotemporal cortex prefrontal cortex task cue

More Related Videos

Conducting Concurrent Electroencephalography and Functional Near-Infrared Spectroscopy Recordings with a Flanker Task

Conducting Concurrent Electroencephalography and Functional Near-Infrared Spectroscopy Recordings with a Flanker Task

Published on: May 24, 2020

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Related Experiment Videos

Last Updated: Oct 20, 2025

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Conducting Concurrent Electroencephalography and Functional Near-Infrared Spectroscopy Recordings with a Flanker Task

Conducting Concurrent Electroencephalography and Functional Near-Infrared Spectroscopy Recordings with a Flanker Task

Published on: May 24, 2020

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Area of Science:

Neuroscience
Cognitive Science
Computational Neuroscience

Background:

Adaptation to environmental changes requires effective information extraction for goal-directed behavior.
Understanding how behavioral flexibility is maintained when relevant cues are ambiguous is a key challenge.

Purpose of the Study:

To investigate the neural mechanisms underlying behavioral flexibility in ambiguously changing environments.
To elucidate the role of brain-wide neural signaling and functional connectivity in task encoding and adaptation.

Main Methods:

Utilized functional brain mapping with machine learning decoders to analyze neural activity.
Employed directional functional connectivity analysis to map information flow.
Investigated neural coding and signaling patterns during ambiguous and explicit behavioral cueing.

Main Results:

Brain-wide reversible neural signaling supports task encoding and behavioral flexibility under ambiguity.
Top-down signals from the prefrontal cortex complement attenuated neural coding in distributed cortical regions during ambiguous cueing.
Bottom-up signals from occipitotemporal regions supplement prefrontal cortex activity during explicit cueing.

Conclusions:

The fronto-occipitotemporal circuit dynamically orchestrates adaptation through alternating top-down and bottom-up signaling.
Neural signaling patterns adjust based on the availability and explicitness of environmental information.
This adaptive mechanism is crucial for navigating an ever-changing world.