Advanced Delivery Systems Based on Lysine or Lysine Polymers
Saeed Manouchehri1, Payam Zarrintaj1, Mohammad Reza Saeb2
1School of Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, Oklahoma 74078, United States.
Molecular Pharmaceutics
|September 14, 2021
Summary
Polylysine, a versatile polymer, offers enhanced intracellular drug delivery. Its unique properties enable smart, stimuli-responsive systems for improved therapeutic agent transport and imaging agent performance.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Polymer Chemistry
Background:
- Polylysine is a cationic macromolecule that interacts electrostatically with cells, facilitating efficient intracellular delivery.
- Its inherent pH-responsiveness can be augmented with various functional groups to create stimuli-responsive drug delivery platforms.
Purpose of the Study:
- To comprehensively review the application of lysine residues, peptides, and polymers in drug delivery systems.
- To provide insights into the design and manufacturing of robust lysine-based delivery platforms.
Main Methods:
- Review of existing literature on polylysine and lysine-based materials in drug delivery.
- Analysis of functionalization strategies to impart stimuli-responsive properties (pH, temperature, hypoxia, redox, enzyme).
- Evaluation of polylysine's role in delivering diverse cargos and enhancing imaging agents.
Main Results:
- Polylysine enables intracellular delivery of small-molecule drugs, genes, proteins, and imaging agents.
- Functionalization enhances polylysine's responsiveness to multiple stimuli, improving therapeutic agent delivery.
- Polylysine modification of contrast agents increases cellular uptake and stability.
Conclusions:
- Lysine-based materials, particularly polylysine, are promising for advanced drug delivery.
- Stimuli-responsive functionalization offers tailored intracellular delivery strategies.
- Further development in design and manufacturing can optimize these platforms for clinical applications.
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