Related Experiment Video
Updated: Oct 20, 2025

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
Weaning from mechanical ventilation in people with neuromuscular disease: a systematic review
Saint Clair Gomes Bernardes Neto1, Rodrigo Torres-Castro2,3, Íllia Lima4
1PneumoCardioVascular Lab/HUOL, Hospital Universitário Onofre Lopes, Empresa Brasileira de Serviços Hospitalares and Departamento de Fisioterapia, Universidade Federal do Rio Grande do Norte, Natal, Brazil netosam@gmail.com.
Objective:
This systematic review aimed in assessing the effects of different weaning protocols in people with neuromuscular disease (NMD) receiving invasive mechanical ventilation, identifying which protocol is the best and how different protocols can affect weaning outcome success, duration of weaning, intensive care unit (ICU) and hospital stay and mortality.
Design:
Systematic review.
Data Sources:
Electronic databases (MEDLINE, EMBASE, Web of Science and Scopus) were searched from January 2009 to August 2020.
Eligibility Criteria For Selecting Studies:
Randomised controlled trials (RCTs) and non-RCT that evaluated patients with NMD (adults and children from 5 years old) in the weaning process managed with a protocol (pressure support ventilation; synchronised intermittent mandatory ventilation; continuous positive airway pressure; 'T' piece).
Primary Outcome:
Weaning success.
Secondary Outcomes:
Weaning duration, ICU stay, hospital stay, ICU mortality, complications (pneumothorax, ventilation-associated pneumonia).
Data Extraction And Synthesis:
Two review authors assessed the titles and the abstracts for inclusion and reviewed the full texts independently.
Results:
We found no studies that fulfilled the inclusion criteria.
Conclusions:
The absence of studies about different weaning protocols for patients with NMD does not allow concluding the superiority of any specific weaning protocol for patients with NMD or determining the impact of different types of protocols on other outcomes. The result of this review encourages further studies.
Prospero Registration Number:
CRD42019117393.
More Related Videos
Related Concept Videos
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation...
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation I: Indication and Settings
Tracheostomy Decannulation
Description of the Procedure
Decannulation refers to the permanent removal of the tracheostomy tube, signaling the resolution of the condition that initially necessitated the tracheostomy. The process requires a well-coordinated interplay between...
Skeletal Muscle Relaxants: Therapeutic Uses
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...

