Extracellular Vesicles: Emerging Therapeutics in Cutaneous Lesions

Area of Science:

• Dermatology
• Nanotechnology
• Biotechnology

Background:

• Extracellular vesicles (EVs) are nanoscale vesicles carrying biomolecules.
• Skin physiology and EV characteristics are fundamental to their application.
• EVs offer potential in skin disease management.

Purpose of the Study:

• To review the role of EVs in skin health and disease.
• To explore therapeutic applications of EVs in dermatology.
• To discuss challenges and future directions for EV-based treatments.

Main Methods:

• Literature review of skin physiology and EV biology.
• Analysis of EV applications in skin infections, inflammatory diseases, repair, and cancer.
• Discussion of plant-derived EVs and clinical trial data.

Main Results:

• EVs possess diverse biomolecular cargo suitable for diagnostics and therapeutics.
• Applications span treatment of infections, inflammation, aging, and cancer.
• Plant-derived EVs and ongoing clinical trials show promise.

Conclusions:

• EVs are versatile tools for dermatological applications.
• Further research and clinical trials are needed to optimize EV-based therapies.
• Overcoming preclinical and clinical challenges will enable widespread adoption.