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Related Experiment Video

Updated: Oct 20, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

A Case of Steroid-Responsive Encephalopathy.

Alona Kondramashin¹, Asia Filatov¹, Jonathan T Grossman¹

¹Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.

|September 15, 2021

Summary

Hashimoto's encephalopathy, an autoimmune thyroiditis complication, presents with gradual neurological symptoms. Prompt steroid treatment can effectively manage this steroid-responsive encephalopathy.

Keywords:

anti-tpo antibodies encephalopathy hashimotos thyroiditis hashimoto’s encephalopathy steroid responsive

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Area of Science:

Neurology
Immunology
Endocrinology

Background:

Hashimoto's encephalopathy (HE) is a rare neurological disorder linked to autoimmune thyroiditis.
It typically manifests with gradual onset neurological symptoms over months.

Observation:

The case involved a 74-year-old male with abrupt confusion.
Diagnosis required identifying elevated anti-thyroid antibodies (anti-TPO or anti-M).
Other findings included elevated ESR, liver enzymes, and CSF protein.

Findings:

HE symptoms encompass cognitive decline, psychiatric disturbances, and motor deficits.
Thyroid function tests and antibody titers do not correlate with disease severity.
Cerebral imaging is often unremarkable.

Implications:

Early diagnosis of HE is crucial for timely intervention.
Steroids, IVIg, or plasmapheresis are effective treatments for HE.
This case highlights the importance of considering autoimmune thyroiditis in encephalopathy presentations.