Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Shape-dependent disassembly of polygonal microparticles in two dimensions.

Soft matter·2026

Same author

Antioxidant Ascorbic Acid Influences Cell-mediated Alterations in Localized Hydrogel Crosslinking and Affects Neo-Cartilage Connectivity in Hydrolytically Degradable Hydrogels.

Macromolecular bioscience·2026

Same author

Siphon-based multichannel acoustofluidic separator for rapid and multiplexed biomolecule detection.

Device·2026

Same author

Genetic control of morphological transitions in a coacervating protein template.

Soft matter·2025

Same author

Transport of Adoptive Cell Transfers With Magnetic Helical Microrobots.

Small (Weinheim an der Bergstrasse, Germany)·2025

Same author

Particle Shape Modulates the Function of Adoptive Macrophage Transfers.

Advanced healthcare materials·2025

Search research articles

Related Experiment Video

Updated: Oct 20, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Magnetic systems for cancer immunotherapy.

Nicole B Day¹, William C Wixson¹, C Wyatt Shields¹

¹Department of Chemical & Biological Engineering, University of Colorado, Boulder, CO 80303, USA.

Acta Pharmaceutica Sinica. B

|September 15, 2021

Summary

Magnetic systems enhance cancer immunotherapy by precisely controlling drug delivery and release. This approach improves treatment efficacy and reduces side effects by targeting tumor sites and modulating immune responses.

Keywords:

BW, body weight Biomaterials CpG, cytosine-phosphate-guanine DAMP, damage associated molecular pattern Drug delivery EPR, enhanced permeability and retention FFR, field free region HS-TEX, heat-stressed tumor cell exosomes HSP, heat shock protein ICD, immunogenic cell death IVIS, in vivo imaging system Immunotherapy MICA, MHC class I-related chain A MPI, magnetic particle imaging Magnetic hyperthermia Magnetic nanoparticles Microrobotics ODNs, oligodeoxynucleotides PARP, poly(adenosine diphosphate-ribose) polymerase PDMS, polydimethylsiloxane PEG, polyethylene glycol PLGA, poly(lactic-co-glycolic acid)PNIPAM, poly(N-isopropylacrylamide)PVA, poly(vinyl alcohol)SDF, stromal cell derived-factor SID, small implantable device SLP, specific loss power

More Related Videos

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Related Experiment Videos

Last Updated: Oct 20, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

Biofunctionalization of Magnetic Nanomaterials

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Area of Science:

Oncology
Biomaterials Science
Nanotechnology

Background:

Immunotherapy offers targeted cancer treatment with higher specificity and efficacy than traditional methods.
Immunosuppressive tumors often inhibit anti-tumoral responses, necessitating novel strategies for immune cell modulation.
Magnetic systems present advantages for enhancing immunotherapy through improved spatiotemporal control.

Purpose of the Study:

To explore the application of magnetic systems in improving cancer immunotherapy.
To review various magnetic strategies for enhancing drug delivery, release, and immune cell stimulation.
To discuss the translational potential and future directions of magnetic-guided immunotherapy.

Main Methods:

Magnetic hyperthermia for immune cell stimulation and thermoresponsive drug release.
Magnetically targeted delivery of drug carriers to tumor sites.
Magnetically driven structural changes in biomaterials for remote drug release.
Utilizing magnetic particles for targeted cellular receptor interactions.

Main Results:

Magnetic systems offer precise control over drug transport, release, and dosing, minimizing off-target effects.
Magnetic hyperthermia can activate immune cells and trigger drug release.
Targeted delivery and magnetically controlled release enhance drug accumulation and efficacy.
Magnetic particle interactions with cellular receptors promote antitumor activity.

Conclusions:

Magnetic systems provide versatile tools for programming immune responses in cancer therapy.
These systems offer enhanced control and efficacy compared to traditional methods.
Further research into toxicity and clinical compatibility is crucial for translational success.